Applied Nursing Research
Volume 17, Issue 4 , Pages 265-274, November 2004

Safety and effectiveness of large-volume enema solutions

Abstract 

The effectiveness and side effects of three types of enema solutions were compared in healthy subjects. Using a repeated-measures, double-blind design, the three different enemas (soapsuds, tap water, and polyethylene glycol-electrolyte solution) were given at 1-week intervals to 24 healthy volunteers. Soapsuds and tap water enemas produced significantly greater returns than polyethylene glycol electrolyte solution (PEG-ES) and were also more uncomfortable. Rectal biopsies showed surface epithelium loss after soapsuds and tap water but not after PEG-ES enemas. Before recommending changes in nursing practice, further research is needed to determine the mechanism for the surface epithelium damage and to determine if this damage produces a stronger defecation stimulus and discomfort.

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 Supported by a grant (#1 R15 NR004867-01) from the National Institute of Nursing Research, Marilee Schmelzer (PI). C.B. Fleets, Inc. donated enema bags and Braintree Laboratories donated NuLYTELY, the polyethylene glycol electrolyte solution.

PII: S0897-1897(04)00080-1

doi:10.1016/j.apnr.2004.09.010

Applied Nursing Research
Volume 17, Issue 4 , Pages 265-274, November 2004